Symbol Name ID |
Abl1
c-abl oncogene 1, non-receptor tyrosine kinase MGI:87859 |
Darker colors indicate more annotations |
Human Phenotypes | Leukocytosis |
Abnormal granulocyte morphology |
Abnormal basophil morphology |
Ph-positive acute lymphoblastic leukemia |
Acute myeloid leukemia |
Chronic myelogenous leukemia |
Myeloproliferative disorder |
Splenomegaly |
Disease(s) Associated with ABL1 | ||||||||
acute myeloid leukemia | ||||||||
chronic myeloid leukemia |
Mouse Phenotypes | abnormal thymus morphology |
thymus cortex hypoplasia |
thymus atrophy |
thymus hypoplasia |
decreased thymocyte number |
enlarged spleen |
abnormal lymphopoiesis |
abnormal B cell differentiation |
decreased immature B cell number |
decreased pro-B cell number |
decreased mature B cell number |
decreased B cell number |
decreased pre-B cell number |
abnormal T cell number |
decreased T cell number |
decreased single-positive T cell number |
increased single-positive T cell number |
decreased lymphocyte cell number |
abnormal spleen morphology |
spleen atrophy |
spleen hypoplasia |
abnormal spleen white pulp morphology |
abnormal spleen germinal center morphology |
abnormal B cell physiology |
abnormal splenocyte physiology |
abnormal immune system cell morphology |
abnormal immune system organ morphology |
enlarged mesenteric lymph nodes |
abnormal peripheral lymph node morphology |
lung inflammation |
increased susceptibility to infection |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||
Abl1m1/Abl1m1 | ||||||||||||||||||||||||||||||||
Abl1tm1Mlg/Abl1tm1Mlg | ||||||||||||||||||||||||||||||||
Abl1tm1Mlg/Abl1tm1Mlg Tg(ACTB-Abl1*K290R)1Spg/0 |
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Abl1tm2.2Goff/Abl1tm2.2Goff | ||||||||||||||||||||||||||||||||
Tg(Igh-Abl1)40Sco/0 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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